Portland is the most populous city in the U.S. state of Oregon, located in the Pacific Northwest region. Situated in the northwestern area of th…Portland is the most populous city in the U.S. state of Oregon, located in the Pacific Northwest region. Situated in the northwestern area of the state at the confluence of the Willamette and Columbia rivers, it is the county seat of Multnomah County, Oregon's most populous county. As of 2020, Portland's population was 652,503, making it the 26th-most populous city in the United States, the sixth-most populous on the West Coast, and the second-most populous in the Pacific Northwest, after Seattle. Approximately 2.5 million people live in the Portland metropolitan area, making it the 25th-most populous in the United States. About half of Oregon's population resides within the Portland metro area.