An investigation has uncovered evidence of significant misreporting, raising new concerns about the approval and long-term use of ticagrelor over the past decade. In a follow-up investigation into the ...

Ticagrelor reversibly inhibits the P2Y12 receptors on platelets, preventing platelet activation and, consequently, aggregation. Unlike the thienopyridines, it does not require metabolic activation.

Ticagrelor is a direct-acting antiplatelet agent that does not depend on metabolic activation and that "reversibly binds" and inhibits the P2Y12 receptor on platelets.

Ticagrelor monotherapy after 3-month dual antiplatelet therapy was not associated with greater risk for repeat revascularization or MACCE at 1 year after PCI vs. continued DAPT, a speaker reported.

Experts suggest that ticagrelor provides considerable added benefit to specific patients by decreasing the risk of death and myocardial infarction. Share: Facebook Twitter Pinterest LinkedIN Email.

Treating coronary artery disease patients with monotherapy using clopidogrel or ticagrelor was associated with lower rates of ...

Ticagrelor versus Clopidogrel in Patients with STEMI Treated with Fibrinolytic Therapy: TREAT Trial. Journal of the American College of Cardiology, 2019; DOI: 10.1016/j.jacc.2019.03.011; ...

Ticagrelor (Brilinta; AstraZeneca) doesn’t lessen risks of MI or death and may increase bleeding relative to clopidogrel, according to the results of a study in a real-world ACS population. Across ...

Between 1 to 12 months after PCI, clinically relevant bleeding occurred in 2.1% of patients in the ticagrelor plus placebo group versus 4.6% of those in the ticagrelor plus aspirin group (HR 0.45 ...

In PLATO, treatment with ticagrelor reduced the combined risk of death from vascular causes, MI, or stroke in patients with ACS with or without STEMI when compared with clopidogrel, while ACS patients ...

March 10, 2010 (Baltimore, Maryland) — The first study to demonstrate that ticagrelor (AstraZeneca) therapy overcomes nonresponsiveness to clopidogrel (Plavix, Bristol-Myers Squibb/Sanofi ...