Nov 29, 2025; Louisville, Kentucky, USA; Louisville Cardinals tight end Nate Kurisky (85) runs the ball against Kentucky Wildcats defensive back Ty Bryant (14) during the second half at L&N Federal Credit Union Stadium. Louisville defeated Kentucky 41-0. Mandatory Credit: Jamie Rhodes-Imagn Images / Jamie Rhodes-Imagn Images

Louisville lost to SMU 38-6, marking the first time the Cardinals have been held without a touchdown since the 2023 ACC Championship Game. Louisville's offense struggled, managing only two field goals and finishing with fewer than 300 total yards.

Louisville is favored by three points against Clemson, per the VegasInsider.com consensus betting line. The point spread opened at Louisville -2.5 and has ticked up slightly. This is Clemson’s first time as a betting underdog this year. ESPN gives Louisville a 54.9% chance of winning.

The Kentucky Wildcats failed their final test of the college football season. Louisville football routed UK in the 2025 Governor's Cup at L&N Stadium.

Louisville running backs Braxton Jennings and Shaun Boykins stepped up for the Cardinals in their win over the Kentucky Wildcats. Louisville's win Saturday was its second straight over Kentucky, the program's first win streak since recording five straight ...

LOUISVILLE, Ky. - The Louisville football program secured a bit time commitment just hours after drubbing Kentucky in the Governor's Cup, with Chuck Alexander Jr. opting to give his verbal pledge to the Cardinals. Here is Louisville Cardinals On SI's full evaluation:

In just their first season of 6A football, the South Warren Spartans entered the final game of the season undefeated, punching their ticket back to the state championship for the first time since 2021.

Laura Ziegler and Elif Istanbulluoglu helped lead No. 20 Louisville women's basketball to its first top-25 win of the season vs. No. 11 North Carolina

This isn't your dad's Louisville vs Memphis basketball rivalry. Pat Kelsey's Louisville Cardinals have far surpassed Penny Hardaway's Memphis Tigers.