Department of Neurology, University of Florida College of Medicine/Shands Hospital, Movement Disorders Center, McKnight Brain Institute, Gainesville, Florida, USA Objective: To determine how ...

Background Neuroaxonal loss occurs in the early stages of multiple sclerosis (MS), but whether it results from early inflammatory brain damage or an ongoing neurodegenerative process remains unclear.

Background and aim: The psychometric properties of rating scales are sample dependent and need evaluations in different samples. The Multiple Sclerosis Impact Scale (MSIS-29), a new patient based ...

OBJECTIVES To evaluate, in people with multiple sclerosis, two psychometric assumptions that must be satisfied for valid use of the medical outcomes study 36-item short form health survey (SF-36): the ...

Professor J D Mitchell, Department of Neurology, Royal Preston Hospital, Sharoe Green Lane, Fulwood, Preston, PR2 9HT, UK. Telephone 0044 1772 710423, fax 0044 1772 718746. OBJECTIVES To seek ...

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Introduction Associations between cerebral small vessel disease (SVD) and inflammation have been largely examined using peripheral blood markers of inflammation, with few studies measuring ...

Advanced neuroimaging has increased understanding of the pathogenesis and spread of disease, and offered new therapeutic targets. MRI and positron emission tomography have shown that neurodegenerative ...

OBJECTIVES To measure the sensitivity and specificity of five MRI sequences to subarachnoid haemorrhage. METHODS Forty one patients presenting with histories suspicious of subarachnoid haemorrhage ...

Objective To explore levels of astrocytopathy in neuromyelitis optica spectrum disorder (NMOSD) by measuring levels of the astrocytic enzyme glutamine synthetase (GS) and glial fibrillary acidic ...

4 Department of Neurosurgery, Royal Prince Alfred Hospital, Camperdown, Sidney, Australia Correspondence to: Dr Nicholas Higgins Department of Radiology, Box 219, Addenbrooke’s Hospital, Hills Road, ...

Objective Although knowledge on poststroke cognitive and functional decline is increasing, little is known about the possible decline of these functions before stroke. We determined the long-term ...