A defining duo of the first Donald Trump administration is back.

Alaska Senator Lisa Murkowski announced that she would not back President Donald Trump’s controversial Pentagon nominee, and Maine Senator Susan Collins has also voiced her disapproval.

Collins was one of two Republican senators to break ranks and oppose Hegseth Thursday, but it didn't stop the nomination from moving forward.

The Alaska Republican plans to vote against the confirmation of Pete Hegseth to lead the Department of Defense.

Sen. Lisa Murkowski announced Thursday that she would vote against confirming Pete Hegseth to lead the Pentagon, becoming the first Republican to oppose one of President Donald Trump’s Cabinet picks. Maine GOP Sen. Susan Collins also voted against Hegseth.

Donald Trump's pick for Defense Secretary, Pete Hegseth, is facing stiff criticism from Democrats—but most Republicans back him.

Two Republicans, Sen. Lisa Murkowski of Alaska and Sen. Susan Collins of Maine, broke ranks and voted against nominating Hegseth.

Pete Hegseth has lost the support of two GOP senators ahead of a final confirmation vote.

Senators voted 51-49 to advance Hegseth's defense secretary bid, which has been mired in a series of controversies. Two Republicans are opposed to Hegseth.

The Senate narrowly advanced the nomination of Pete Hegseth as President Donald Trump’s defense secretary on Thursday in a 51-49 vote, moving him one step closer to confirmation despite fierce objections from Senate Democrats and mounting unease among some Republicans.

The Alaska senator announced on Thursday that “she cannot in good conscience” support Pete Hegseth’s nomination for Defense Secretary.