BACKGROUND: Heart failure with preserved ejection fraction (HFpEF) is a major health concern. Pathological stimuli and interactions between cardiac fibroblasts (CFs) and other cell types may lead to ...

As the most upstream component of the renin-angiotensin-aldosterone system, angiotensinogen represents an attractive target ...

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Mitochondrial dysfunction is a key factor in the development of atherogenesis. METTL4 (methyltransferase-like protein 4) mediates N6- methyldeoxyadenosine (6mA) of mammalian mitochondrial DNA (mtDNA).

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Our vision is to innovate and incorporate promising technologies to communicate freely available, high-priority, high-quality content, which accelerates scientific progress and advances heart and ...

Figure 1. Age-standardized stroke disability-adjusted life-years (DALYs) and mortality rates per 100,000 person-years in various regions of the world in 2013 (both sexes, all ages) Although stroke ...

In the current issue of Circulation, Mehta and colleagues compared 1-year saphenous vein graft failure (defined as ≥75% angiographic stenosis or occlusion) and 5-year clinical events (composite of ...

Myocardial infarction (MI) is a complex disease caused by both lifestyle and genetic factors. This study aims to investigate the predictive value of genetic risk, in addition to traditional ...

Department of Physiology and Cardiothoracic Surgery, Cardiovascular R&D Centre – UnIC@RISE, Faculty of Medicine of the University of Porto, Portugal (J.P.F.). Heart Failure Clinic, Internal Medicine ...