Panama President José Raúl Mulino said Thursday there will be no negotiation with the United States over ownership of the Panama Canal, and he hopes U.S. Secretary of State Marco Rubio’s upcoming visit will allow them to focus on shared interests including migration and combating drug trafficking.

Newly inaugurated U.S. President Donald Trump is pushing to "take back" the Panama Canal, the world's second busiest interoceanic waterway.

Panamanian President Jose Raul Mulino on Thursday ruled out discussing control over the Panama Canal in a meeting with U.S. Secretary of State Marco Rubio, who is set to visit the Central American country in his first official trip abroad this weekend.

Rubio said he could not predict if Trump would succeed in buying Greenland from Denmark or restoring American authority over the Panama Canal while he is in office.

In recent weeks, when he was President-elect Donald Trump publicly said that Panama should return the Panama Canal to the United States, and he would not rule out using military force to reclaim it. At his presidential Inauguration on Monday Trump doubled down on saying that his new administration was going to take back the canal.

When Marco Rubio arrives in Latin America this weekend on his first foreign trip as Donald Trump's secretary of state, he'll find a region reeling from the new administration's shock-and-awe approach to diplomacy.

Rubio defended Trump's proposed territorial expansions as a 'national interest,' while Denmark and Greenland firmly rejected offers amid concerns over potential military action.